Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Norleual TFA | 99.9% | 888.97 | 1 MG
Norleual TFA is an angiotensin (Ang) IV analog and a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. It acts as an AT4 receptor antagonist and demonstrates potent antiangiogenic activities. It significantly reduces HGF-dependent c-Met and Gab1 phosphorylation and attenuates HGF-dependent c-Met activation and downstream signaling. In vivo, Norleual TFA suppresses pulmonary colonization by B16-F10 murine melanoma cells.
- Reduces HGF-dependent c-Met and Gab1 phosphorylation
- Attenuates HGF-dependent c-Met activation and downstream signaling
- Inhibits HGF-dependent signaling, proliferation, migration, and invasion in multiple cell types
- Suppresses pulmonary colonization by B16-F10 murine melanoma cells
Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.8% | 987.96 | 5 MG
SJ1008030 TFA is a JAK2 PROTAC that selectively degrades JAK2. It inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM and can be utilized for leukemia research. The compound is composed of a JAK2 ligand, a Cereblon ligand, and a linker.
- Selective JAK2 PROTAC degrader.
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Can be used for leukemia research.
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH-CALL-4 cells.
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating inhibition of the JAK-STAT signaling pathway.
Medchemexpress LLC Cpn-267 tfa | 1279.27 | 1 MG
Cpn-267 tfa is a selective agonist for neuromedin U receptor 1 (NMUR1) with an EC50 of 0.25 nM. This compound has been shown to suppress body weight gain in mice, suggesting its potential use in the study of obesity. It is provided as a solid for research applications.
- Selective NMUR1 agonist.
- Potent activity at nanomolar concentrations.
- Demonstrated suppression of body weight gain in animal models.
- Suitable for obesity research.
Medchemexpress LLC 7-TFA-ap-7-Deaza-dA | 178420-75-2 | 98.8% | 399.32 | 1 ML
7-TFA-ap-7-Deaza-dA is a modified nucleoside that can be used in the synthesis of deoxyribonucleic acid or nucleic acid. It functions as a click chemistry reagent, containing an alkyne group that undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Modified nucleoside.
- Can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
- Functions as a click chemistry reagent.
- Contains an alkyne group for reactions.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
Medchemexpress LLC Reltecimod TFA | 1447799-33-8 | ≥98% | 1037.19 | 25 MG
Reltecimod TFA is a T cell-specific surface glycoprotein CD28 (TP44) antagonist. It demonstrates good resistance to various bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 costimulatory pathway without inhibiting it. It may be used to study necrotizing soft tissue infections (NSTIs).
- T cell-specific surface glycoprotein CD28 (TP44) antagonist
- Good resistance to different bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation
- Modulates inflammatory response by attenuating the CD28/B7-2 costimulatory pathway
- May be utilized to study necrotizing soft tissue infections (NSTIs)
- Increases survival rate of mice harboring several bacterial infections (at 1.25-5 mg/kg; iv)
TARGETMOL CHEMICALS INC Dermorphin TFA 2MG
Also available in 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Dermorphin TFA is a new class of opioids-like peptides Purity 100%
eMolecules 76-05-1 | Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 500g | 537709017
Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 500g | 537709017
Medchemexpress LLC Iberiotoxin TFA | 99.4% | 4230.85 | 1 MG
Iberiotoxin (TFA) is a potent and selective inhibitor of high conductance Ca2+-activated K+ channels. This compound demonstrates high affinity for its target with a Kd of approximately 1 nM, and it specifically targets these channels without affecting other types of voltage-dependent ion channels.
- Selective inhibitor of high conductance Ca2+-activated K+ channels.
- High affinity with a Kd of ~1 nM.
- Does not block other types of voltage-dependent ion channels.
Medchemexpress LLC Myr-FEEERA-OH (TFA) | 990.15 | 25 MG
mP6 (Myr-FEEERA-OH) is a myristoylated peptide. It inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function, and can block the GTP usage of Rac1, Rap1, and Rab7.
- Effectively inhibits the infection of CHO-A24 cells
- Myristoylated peptide
- Inhibits interaction of Gα13 with integrin β3
- Blocks GTP usage of Rac1, Rap1, and Rab7
Medchemexpress LLC Trifluoroacetic acid-13C sodium | 286425-32-9 | 98.0% | 137.00 g/mol | C13CF3NaO2 | 1mg
Trifluoroacetic acid-13C sodium is the 13C labeled isotope of Trifluoroacetic acid-13C (sodium) (HY-W754811)[1]