Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC PBA-1105 TFA | 99.6% | 754.83 | 5 MG
PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. It selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. This compound increases the autophagic flux of Ub-conjugated aggregates and induces autophagic degradation of misfolded proteins and aggregates at nanomolar concentrations. It is for research use only.
- Induces p62 self-oligomerization.
- Selectively binds to exposed hydrophobic regions of misfolded proteins.
- Facilitates degradation via the autophagic pathway.
- Increases the autophagic flux of Ub-conjugated aggregates.
- Induces autophagic degradation of mutant tau and misfolded proteins.
Medchemexpress LLC Boc-Met-Leu-Phe (trifluoroacetate) | 00-00-0 | MFCD00037435 | 99.5% | 623.68 g/mol | C27H40F3N3O8S | 1 ML
Boc-MLF TFA is a Boc-protected tripeptide (Boc-Met-Leu-Phe as the trifluoroacetate salt) used as a formyl peptide receptor (FPR) antagonist for receptor pharmacology and cell signaling studies. It is supplied as a 10 mM solution in DMSO (1 mL) or as a dry powder and is offered with high reported purity for research applications.
- Acts as a formyl peptide receptor (FPR) antagonist.
- Inhibits formyl peptide receptor like 1 (FPRL1) at higher concentrations.
- Available as a 10 mM solution in DMSO (1 mL) or as dry powder formats.
- High reported purity suitable for biochemical assays (~99.5%).
- Contains Boc-protected Met-Leu-Phe sequence as the trifluoroacetate salt.
Medchemexpress LLC Gmprga Tfa | 98.1% | 5 MG
GMPRGA TFA is the trifluoroacetic acid (TFA) salt form of GMPRGA. It is known to recognize spAimR in the bacterial cytosol, a process that induces lysogeny.
- TFA salt form
- Recognizes spAimR in bacterial cytosol
- Induces lysogeny
- Functions as an inhibitor
- Part of bacterial lysis-lysogeny studies
- Classified as an antimicrobial peptide
Medchemexpress LLC Frakefamide TFA 10mM 1mL | 10MM 1ML
Frakefamide TFA is a potent analgesic that acts as a peripheral active -selective receptor agonist Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1 [2
Medchemexpress LLC LP17 TFA (LQVTDSGLYRCVIYHPP TFA) | 99.2% | 1961.24 | 5 MG
LP17 (LQVTDSGLYRCVIYHPP) TFA is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. It substantially alleviates ischemia-induced infarction and neuronal injury by accessing the brain and blocking TREM-1. For research use only.
- Decreases mRNA levels of pro-inflammatory cytokines and chemokines.
- Attenuates extracellular protein levels of IL-1β and IL-18 in a microglia oxygen-glucose deprivation (OGD) model.
- Interacts with microglial SYK.
- Alleviates ischemia-induced infarction and neuronal injury in mice.
- Reduces infarct volume by 27.3%.
- Reduces TUNEL positive cells and FJC positive neurons.
- Rescues neurological deficits and cognitive dysfunction.
- Inhibits microglial M1 polarization and neutrophil infiltration.
Medchemexpress LLC Gsnkskpk-nh2 (TFA) | 99.9% | 843.97 (free base) | 5 MG
GSNKSKPK-NH2 TFA is a model peptide based on a c-Src N-terminal peptide, which serves as an NMT substrate.
- Purity: 99.9%
- Appearance: White to off-white solid
- Sequence: Gly-Ser-Asn-Lys-Ser-Lys-Pro-Lys-NH2
- Molecular formula: C35H65N13O11.xC2HF3O2
- Soluble in water and DMSO
Medchemexpress LLC Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) | 96.6% | 7588.60 (free base) | 1 MG
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide and the main toxin found in scorpion venom. This peptide specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6, making it a valuable tool for research in ion channel modulation and neurological diseases.
- Neurotoxic peptide
- Specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6
- Functions as an ion channel modulator
- Useful in neurological disease research
- Acts as an inhibitor
Medchemexpress LLC 6bK (TFA) | 1774353-12-6 | MFCD30182289 | 99.4% | 871.94 g/mol | C43H56F3N7O9 | 5 MG
6bK TFA is a potent, selective insulin-degrading enzyme (IDE) inhibitor used in preclinical research to study insulin metabolism and glucose tolerance. It shows an in vitro IC50 of approximately 50 nM and has been reported to increase circulating insulin and improve oral glucose tolerance in high-fat-fed mice.
- Potent IDE inhibition (IC50 ≈ 50 nM).
- Selective activity for insulin-degrading enzyme.
- High purity (≈99.4%).
- Available as solid and DMSO solution in multiple pack sizes.
- Supplied with analytical documents (COA, HPLC, LCMS).
- Recommended storage: solid -20°C; in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Glycyl-Exatecan TFA | 1883333-57-0 | 96.9% | 1 MG
Glycyl-Exatecan TFA is an anticancer agent derived from Exatecan. It exhibits significant antitumor activity and is suitable for research on cancers such as solid tumors.
- Anticancer agent
- Derivative of Exatecan
- Exhibits significant antitumor activity
- Utilized in research for various cancers, including solid tumors
- Store at -20°C, protected from light and under nitrogen
Medchemexpress LLC Homoglutathione TFA | 95.0% | 435.37 | C13H20F3N3O8S | 5mg
Homoglutathione (TFA) is a biological molecule
Medchemexpress LLC Valylleucine TFA | 27530-02-5 | 99.3% | 344.33 | 25 MG
Valylleucine TFA is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. It can be used for protein interaction, functional analysis, and epitope screening, especially in agent research and development.
- Polypeptide
- Used in peptide screening
- Pools active peptides by immunoassay
- Supports protein interaction studies
- Enables functional analysis
- Facilitates epitope screening
- Applicable in agent research and development